Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.

mBio - 13 Dec 2016

Fehr Anthony R, Channappanavar Rudragouda, Jankevicius Gytis, Fett Craig, Zhao Jincun, Athmer Jeremiah, Meyerholz David K, Ahel Ivan, Perlman Stanley

Abstract excerpt

ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets. All members of the Coronavirinae, a subfamily of positive-sense RNA viruses, contain a highly conserved macrodomain within nonstructural protein 3 (nsp3). However, its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Bronchi

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coinfection

Share to Coronavirus

Share to Protein Domains

Share to Severe Acute Respiratory Syndrome

Share to Severe acute respiratory syndrome-related coronavirus

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27965448
DOI: 10.1128/mBio.01721-16
PMCID: PMC5156301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.PMID 27965448Read ↗

Mutation of a highly conserved isoleucine residue in loop 2 of several 𝛽-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infectionSemantic proximity Read ↗

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice.Semantic proximity Read ↗

Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.Semantic proximity Read ↗

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replicationSemantic proximity Read ↗

Host ADP-ribosylation and the SARS-CoV-2 macrodomainSemantic proximity Read ↗

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced EncephalitisSemantic proximity Read ↗

The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-RibosylhydrolaseSemantic proximity Read ↗

The ADP-ribose-1″-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responsesSemantic proximity Read ↗

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation.Semantic proximity Read ↗

Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-ribosyl Hydrolase ActivitySemantic proximity Read ↗

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signallingSemantic proximity Read ↗

Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.