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Article

APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice.

Molecular neurodegeneration - 31 Jan 2017

Pankiewicz Joanna E, Baquero-Buitrago Jairo, Sanchez Sandrine, Lopez-Contreras Jennifer, Kim Jungsu, Sullivan Patrick M, Holtzman David M, Sadowski Martin J

Abstract excerpt

BACKGROUND: APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer's disease (AD). Here we investigated how APOE genotype influences response to anti-Aβ immunotherapy. METHODS: APPSW/PS1dE9 (APP) transgenic mice with targeted replacement of the murine Apoe gene for human APOE alleles received 10D5 anti-Aβ or TY11-15 isotype control antibodies between the...

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Source

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Identifiers

PMID: 28143566
DOI: 10.1186/s13024-017-0156-1
PMCID: PMC5282859

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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