Article
Stereoisomers Probe Steric Zippers in Amyloid-β.
The journal of physical chemistry. B - 2 Mar 2017
Chandra Bappaditya, Korn Alexander, Maity Barun Kumar, Adler Juliane, Rawat Anoop, Krueger Martin, Huster Daniel, Maiti Sudipta
Abstract excerpt
Shape complementarity between close-packed residues plays a critical role in the amyloid aggregation process. Here, we probe such "steric zipper" interactions in amyloid-β (Aβ40), whose aggregation is linked to Alzheimer's disease, by replacing natural residues by their stereoisomers. Such mutations are expected to specifically destabilize the shape sensitive "packing" interactions, which may potentially increase...
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