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Article

Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2.

Neuroepidemiology - 1 Jan 2016

Chuang Yu-Hsuan, Lill Christina M, Lee Pei-Chen, Hansen Johnni, Lassen Christina F, Bertram Lars, Greene Naomi, Sinsheimer Janet S, Ritz Beate

Abstract excerpt

BACKGROUND AND PURPOSE: Drinking caffeinated coffee has been reported to provide protection against Parkinson's disease (PD). Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD...

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Identifiers

PMID: 28135712
DOI: 10.1159/000450855
PMCID: PMC5465963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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