Article
Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions.
Parkinsonism & related disorders - 1 Jun 2013
Chung Sun Ju, Armasu Sebastian M, Anderson Kari J, Biernacka Joanna M, Lesnick Timothy G, Rider David N, Cunningham Julie M, Ahlskog J Eric, Frigerio Roberta, Maraganore Demetrius M
Abstract excerpt
BACKGROUND: Prior studies causally linked mutations in SNCA, MAPT, and LRRK2 genes with familial Parkinsonism. Genome-wide association studies have demonstrated association of single nucleotide polymorphisms (SNPs) in those three genes with sporadic Parkinson's disease (PD) susceptibility worldwide. Here we investigated the interactions between SNPs in those three susceptibility genes and environmental exposures...
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