Article
Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease.
European journal of neurology - 1 May 2011
Popat R A, Van Den Eeden S K, Tanner C M, Kamel F, Umbach D M, Marder K, Mayeux R, Ritz B, Ross G W, Petrovitch H, Topol B, McGuire V, Costello S, Manthripragada A D, Southwick A, Myers R M, Nelson L M
Abstract excerpt
BACKGROUND AND PURPOSE: In 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine animal models of Parkinson's disease (PD), caffeine protects neurons by blocking the adenosine receptor A2A (ADORA2A). Caffeine is primarily metabolized by cytochrome P450 1A2 (CYP1A2). Our objective was to examine whether ADORA2A and CYP1A2 polymorphisms are associated with PD risk or modify the caffeine-PD association. METHODS: Parkinson's...
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