Article
Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2018
Kim Iris Y, O'Reilly Éilis J, Hughes Katherine C, Gao Xiang, Schwarzschild Michael A, McCullough Marjorie L, Hannan Marian T, Betensky Rebecca A, Ascherio Alberto
Abstract excerpt
BACKGROUND: Caffeine intake has been inversely associated with Parkinson's disease (PD) risk. This relationship may be modified by polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2), but the results of previous studies have been inconsistent. METHOD: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in...
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