Article
Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee.
PLoS genetics - 1 Aug 2011
Hamza Taye H, Chen Honglei, Hill-Burns Erin M, Rhodes Shannon L, Montimurro Jennifer, Kay Denise M, Tenesa Albert, Kusel Victoria I, Sheehan Patricia, Eaaswarkhanth Muthukrishnan, Yearout Dora, Samii Ali, Roberts John W, Agarwal Pinky, Bordelon Yvette, Park Yikyung, Wang Liyong, Gao Jianjun, Vance Jeffery M, Kendler Kenneth S, Bacanu Silviu-Alin, Scott William K, Ritz Beate, Nutt John, Factor Stewart A, Zabetian Cyrus P, Payami Haydeh
Abstract excerpt
Our aim was to identify genes that influence the inverse association of coffee with the risk of developing Parkinson's disease (PD). We used genome-wide genotype data and lifetime caffeinated-coffee-consumption data on 1,458 persons with PD and 931 without PD from the NeuroGenetics Research Consortium (NGRC), and we performed a genome-wide association and interaction study (GWAIS), testing each SNP's main-effect...
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