Article
Genomewide Association Study Identifies Copy Number Variants Associated With Warfarin Dose Response and Risk of Venous Thromboembolism in African Americans.
Clinical pharmacology and therapeutics - 1 Mar 2023
Zhang Honghong, Alarcon Cristina, Cavallari Larisa H, Nutescu Edith, Carvill Gemma L, Perera Minoli A, Hernandez Wenndy
Abstract excerpt
The anticoagulant warfarin is commonly used to control and prevent thrombotic disorders, such as venous thromboembolism (VTE), which disproportionately afflicts African Americans. Despite the importance of copy number variants (CNVs), few studies have focused on characterizing and understanding their role in drug response and disease risk among African Americans. In this study, we conduct the first genome-wide...
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