YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

doi:10.1073/pnas.1620290114

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Article

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017

Taniguchi Koji, Moroishi Toshiro, de Jong Petrus R, Krawczyk Michal, Grebbin Britta Moyo, Luo Huiyan, Xu Rui-Hua, Golob-Schwarzl Nicole, Schweiger Caroline, Wang Kepeng, Di Caro Giuseppe, Feng Ying, Fearon Eric R, Raz Eyal, Kenner Lukas, Farin Henner F, Guan Kun-Liang, Haybaeck Johannes, Datz Christian, Zhang Kang, Karin Michael

Abstract excerpt

Loss of tumor suppressor adenomatous polyposis coli (APC) activates β-catenin to initiate colorectal tumorigenesis. However, β-catenin (CTNNB1) activating mutations rarely occur in human colorectal cancer (CRC). We found that APC loss also results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating Src family kinases (SFKs), YAP, and STAT3, which are simultaneously up-regulated in the...

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Identifiers

PMID: 28130546
DOI: 10.1073/pnas.1620290114
PMCID: PMC5320959

Genes

APC
CTNNB1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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