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Article

SRC activates TAZ for intestinal tumorigenesis and regeneration.

Cancer letters - 1 Dec 2017

Byun Mi Ran, Hwang Jun-Ha, Kim A Rum, Kim Kyung Min, Park Jung Il, Oh Ho Taek, Hwang Eun Sook, Hong Jeong-Ho

Abstract excerpt

Proto-oncogene tyrosine-protein kinase Src (cSRC) is involved in colorectal cancer (CRC) development and damage-induced intestinal regeneration, although the cellular mechanisms involved are poorly understood. Here, we report that transcriptional coactivator with PDZ binding domain (TAZ) is activated by cSRC, regulating CRC cell proliferation and tumor formation, where cSRC overexpression increases TAZ expression...

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Source

Identifiers

PMID: 28939028
DOI: 10.1016/j.canlet.2017.09.003

Genes

SRC
TEAD4
TEF

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