Article
Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism.
Gastroenterology - 1 Jan 2022
Vu Trung, Datta Arunima, Banister Carolyn, Jin Lin, Yuan Guandou, Samuel Temesgen, Bae Sejong, Eltoum Isam-Eldin, Manne Upender, Zhang Bixiang, Welner Robert S, Mitra Kasturi, Buckhaults Phillip, Datta Pran K
Abstract excerpt
BACKGROUND & AIMS: Inactivation of the Apc gene is a critical early event in the development of sporadic colorectal cancer (CRC). Expression of serine-threonine kinase receptor-associated protein (STRAP) is elevated in CRCs and is associated with poor outcomes. We investigated the role of STRAP in Apc mutation-induced intestinal tumor initiation and progression. METHODS: We generated Strap intestinal epithelial...
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