Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer

15 Jan 2014

Abstract excerpt

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer 'hallmarks' through downstream activation of the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. Additionally, dysregulation of the interleukin (IL)-6-mediated JAK/STAT3 signaling pathway is closely related to the development of diverse human solid tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Medicinal Plant Pharmacodynamics Research
Share to Pharmacological Effects of Natural Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24430672
DOI: 10.3892/ijo.2014.2259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancerPMID 24430672Read ↗

Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC.Semantic proximity Read ↗

Targeting the Interleukin-6/Jak/Stat Pathway in Human MalignanciesSemantic proximity Read ↗

Signaling Molecules: The Pathogenic Role of the IL-6/STAT-3 Trans Signaling Pathway in Intestinal Inflammation and in Colonic CancerSemantic proximity Read ↗

A Potential Role of IL-6/IL-6R in the Development and Management of Colon CancerSemantic proximity Read ↗

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated CancerSemantic proximity Read ↗

The IL6/JAK/STAT3 pathway as a therapeutic target for histological subtypes of colorectal cancerSemantic proximity Read ↗

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancerSemantic proximity Read ↗

The Role of Interleukins in Colorectal Cancer.Semantic proximity Read ↗

Signal Transducer and Activator of Transcription 3 - A Promising Target in Colitis-Associated CancerSemantic proximity Read ↗

The role of IL-6 and STAT3 in inflammation and cancerSemantic proximity Read ↗

Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer developmentSemantic proximity Read ↗

LNRRIL 6, a novel long noncoding RNA , protects colorectal cancer cells by activating the IL ‐6– STAT 3 pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.