Article
Thymidylate synthase polymorphism in sporadic colorectal and gastric cancer in Tunisian population: a predictive role in 5-fluorouracil based chemotherapy treatment.
Medical oncology (Northwood, London, England) - 1 Feb 2014
Baroudi Olfa, Baroudi Thouraya, Omrane Ines, Moussa Amel, Mezlini Amel, Ayari Hajer, Guermazi Sami, Bahloul Abdesslem, Bouzaienne Hassen, Uhrhammer Nancy, Bignon Yves Jean, El-Gaaied Amel Benammar, Bougatef Karim
Abstract excerpt
In our study, we investigate the possible association of thymidylate synthase polymorphism, 28 bp tandem repeat in 5'-UTR (transcription enhancer element) with susceptibility of colorectal and gastric cancer in Tunisian population. Because thymidylate synthase provides an effective prediction of chemotherapy treatment based on 5-fluorouracil, our interest in this study was focused on finding an eventual...
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