Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer.

doi:10.1515/dmpt-2017-0028

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Article

Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer.

Drug metabolism and personalized therapy - 20 Dec 2017

Castro-Rojas Carlos A, Esparza-Mota Antonio R, Hernandez-Cabrera Francisco, Romero-Diaz Viktor J, Gonzalez-Guerrero Juan F, Maldonado-Garza Hector, Garcia-Gonzalez Irma S, Buenaventura-Cisneros Sergio, Sanchez-Lopez Josefina Y, Ortiz-Lopez Rocio, Camacho-Morales Alberto, Barboza-Quintana Oralia, Rojas-Martinez Augusto

Abstract excerpt

BACKGROUND: Fluoropyrimidines form the chemotherapy backbone of advanced and metastatic colorectal cancer (CRC). These drugs are frequently associated with toxicity events that result in dose adjustments and even suspension of the treatment. The thymidylate synthase (TYMS) gene is a potential marker of response and toxicity to fluoropyirimidines as this enzyme is the molecular target of these drugs. Our aim was...

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PMID: 29257755
DOI: 10.1515/dmpt-2017-0028

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TYMS

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