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Article

Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.

The Biochemical journal - 15 Aug 2008

van Rijn Richard M, van Marle André, Chazot Paul L, Langemeijer Ellen, Qin Yongjun, Shenton Fiona C, Lim Herman D, Zuiderveld Obbe P, Sansuk Kamonchanok, Dy Michel, Smit Martine J, Tensen Cornelis P, Bakker Remko A, Leurs Rob

Abstract excerpt

The H(4)R (histamine H(4) receptor) is the latest identified member of the histamine receptor subfamily of GPCRs (G-protein-coupled receptors) with potential functional implications in inflammatory diseases and cancer. The H(4)R is primarily expressed in eosinophils and mast cells and has the highest homology with the H(3)R. The occurrence of at least twenty different hH(3)R (human H(3)R) isoforms led us to...

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Identifiers

PMID: 18452403
DOI: 10.1042/BJ20071583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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