Article
G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure.
The pharmacogenomics journal - 1 Jan 2001
Fukushima Y, Saitoh T, Anai M, Tsukuda K, Onishi Y, Sakoda H, Inukai K, Ogihara T, Funaki M, Ono H, Fujishiro M, Ishikawa T, Nagai R, Omata M, Asano T
Abstract excerpt
Orange et al reported an allelic variant of the human histamine H2 receptor, in which adenine 649 was replaced with guanine, to be more frequent in the schizophrenic population than controls in British Caucasians. The A649 to G change causes an Asn to Asp transition at amino acid position 217 in the third intracellular region, which is postulated to be important for receptor function. Herein, we analyzed the...
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