Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.

doi:10.1186/s13059-016-1142-6

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Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.

Genome biology - 25 Jan 2017

Joehanes Roby, Zhang Xiaoling, Huan Tianxiao, Yao Chen, Ying Sai-Xia, Nguyen Quang Tri, Demirkale Cumhur Yusuf, Feolo Michael L, Sharopova Nataliya R, Sturcke Anne, Schäffer Alejandro A, Heard-Costa Nancy, Chen Han, Liu Po-Ching, Wang Richard, Woodhouse Kimberly A, Tanriverdi Kahraman, Freedman Jane E, Raghavachari Nalini, Dupuis Josée, Johnson Andrew D, O'Donnell Christopher J, Levy Daniel, Munson Peter J

Abstract excerpt

BACKGROUND: Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as expression quantitative trait loci (eQTLs), may improve understanding of the functional role of phenotype-associated SNPs in genome-wide association studies (GWAS). The small sample sizes of some previous eQTL studies have limited their statistical power. We conducted an eQTL investigation of...

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PMID: 28122634
DOI: 10.1186/s13059-016-1142-6
PMCID: PMC5264466

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