Article
Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes.
Human molecular genetics - 1 Feb 2014
Zhang Xiaoling, Johnson Andrew D, Hendricks Audrey E, Hwang Shih-Jen, Tanriverdi Kahraman, Ganesh Santhi K, Smith Nicholas L, Peyser Patricia A, Freedman Jane E, O'Donnell Christopher J
Abstract excerpt
Genome-wide association studies (GWAS) have uncovered many genetic associations for cardiovascular disease (CVD). However, data are limited regarding causal genetic variants within implicated loci. We sought to identify regulatory variants (cis- and trans-eQTLs) affecting expression levels of 93 genes selected by their proximity to SNPs with significant associations in prior GWAS for CVD traits. Expression levels...
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