Article
Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart.
PloS one - 1 Jan 2014
Koopmann Tamara T, Adriaens Michiel E, Moerland Perry D, Marsman Roos F, Westerveld Margriet L, Lal Sean, Zhang Taifang, Simmons Christine Q, Baczko Istvan, dos Remedios Cristobal, Bishopric Nanette H, Varro Andras, George Alfred L, Lodder Elisabeth M, Bezzina Connie R
Abstract excerpt
In recent years genome-wide association studies (GWAS) have uncovered numerous chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia predisposition. A considerable fraction of these loci lie within inter-genic regions. The underlying trait-associated variants likely reside in regulatory regions and exert their effect by modulating gene expression. Hence, the key to unraveling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.