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Kemp Elimination Catalyzed by Naturally Occurring Aldoxime Dehydratases.

Chembiochem : a European journal of chemical biology - 2 Mar 2017

Miao Yufeng, Metzner Richard, Asano Yasuhisa

Abstract excerpt

Recently, the Kemp elimination reaction has been extensively studied in computational enzyme design of new catalysts, as no natural enzyme has evolved to catalyze this reaction. In contrast to in silico enzyme design, we were interested in searching for Kemp eliminase activity in natural enzymes with catalytic promiscuity. Based on similarities of substrate structures and reaction mechanisms, we assumed that the...

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PMID: 28120515
DOI: 10.1002/cbic.201600596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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