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Article

Kemp Eliminase Activity of Ketosteroid Isomerase.

Biochemistry - 31 Jan 2017

Lamba Vandana, Sanchez Enis, Fanning Lauren Rose, Howe Kathryn, Alvarez Maria Alejandra, Herschlag Daniel, Forconi Marcello

Abstract excerpt

Kemp eliminases represent the most successful class of computationally designed enzymes, with rate accelerations of up to 109-fold relative to the rate of the same reaction in aqueous solution. Nevertheless, several other systems such as micelles, catalytic antibodies, and cavitands are known to accelerate the Kemp elimination by several orders of magnitude. We found that the naturally occurring enzyme...

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Identifiers

PMID: 28045505
DOI: 10.1021/acs.biochem.6b00762
PMCID: PMC5446047

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