Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2010

Frushicheva Maria P, Cao Jie, Chu Zhen T, Warshel Arieh

Abstract excerpt

One of the fundamental challenges in biotechnology and in biochemistry is the ability to design effective enzymes. Doing so would be a convincing manifestation of a full understanding of the origin of enzyme catalysis. Despite an impressive progress, most of the advances on this front have been m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Computer Simulation
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lyases

Share to Models, Chemical

Share to Mutation

Share to Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 20829491
DOI: 10.1073/pnas.1010381107
PMCID: PMC2947920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20829491-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase.PMID 20829491Read ↗

Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution.Semantic proximity Read ↗

Natural Evolution Provides Strong Hints about Laboratory Evolution of Designer Enzymes.Semantic proximity Read ↗

Complete computational design of high-efficiency Kemp elimination enzymes.Semantic proximity Read ↗

Enriching productive mutational paths accelerates enzyme evolution.Semantic proximity Read ↗

Comparison of designed and randomly generated catalysts for simple chemical reactions.Semantic proximity Read ↗

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico.Semantic proximity Read ↗

Kemp Eliminase Activity of Ketosteroid Isomerase.Semantic proximity Read ↗

Kemp Elimination Catalyzed by Naturally Occurring Aldoxime Dehydratases.Semantic proximity Read ↗

Computational tools for designing and engineering biocatalysts.Semantic proximity Read ↗

Organophosphate Hydrolysis by a Designed Metalloenzyme: Impact of Mutations Explained.Semantic proximity Read ↗

Artificial enzymes bringing together computational design and directed evolution.Semantic proximity Read ↗

Origin of the activity drop with the E50D variant of catalytic antibody 34E4 for Kemp elimination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.