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Article

Generation of a Mouse Model with Smooth Muscle Cell Specific Loss of the Expression of PPARγ.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Rautureau Yohann, Paradis Pierre, Schiffrin Ernesto L

Abstract excerpt

An inducible tissue-specific knockout (KO) technique has been used to study the role of genes in the adult heart. This KO technique circumvents the developmental effect that could otherwise be observed in a tissue-specific KO. The peroxisome proliferator-activated receptor (PPAR) γ is a transcription factor that when activated has been shown to improve vascular remodeling and endothelial function in hypertensive...

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PMID: 28116732
DOI: 10.1007/978-1-4939-6625-7_30

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