Article
Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2017
Mukohda Masashi, Lu Ko-Ting, Guo Deng-Fu, Wu Jing, Keen Henry L, Liu Xuebo, Ketsawatsomkron Pimonrat, Stump Madeliene, Rahmouni Kamal, Quelle Frederick W, Sigmund Curt D
Abstract excerpt
Selective expression of dominant negative (DN) peroxisome proliferator-activated receptor γ (PPARγ) in vascular smooth muscle cells (SMC) results in hypertension, atherosclerosis, and increased nuclear factor-κB (NF-κB) target gene expression. Mesenteric SMC were cultured from mice designed to conditionally express wild-type (WT) or DN-PPARγ in response to Cre recombinase to determine how SMC PPARγ regulates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.