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Article

PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity.

Circulation research - 9 Nov 2012

Ketsawatsomkron Pimonrat, Lorca Ramón A, Keen Henry L, Weatherford Eric T, Liu Xuebo, Pelham Christopher J, Grobe Justin L, Faraci Frank M, England Sarah K, Sigmund Curt D

Abstract excerpt

RATIONALE: Activation of peroxisome proliferator-activated receptor-γ (PPARγ) by thiazolidinediones lowers blood pressure, whereas PPARγ mutations cause hypertension. Previous studies suggest these effects may be mediated through the vasculature, but the underlying mechanisms remain unclear. OBJECTIVE: To identify PPARγ mechanisms and transcriptional targets in vascular smooth muscle and their role in regulating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22962432
DOI: 10.1161/CIRCRESAHA.112.271577
PMCID: PMC3494760

Genes

RGS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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