Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease.

doi:10.1016/j.jalz.2013.11.001

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2014

Morgen Katrin, Ramirez Alfredo, Frölich Lutz, Tost Heike, Plichta Michael M, Kölsch Heike, Rakebrandt Fabian, Rienhoff Otto, Jessen Frank, Peters Oliver, Jahn Holger, Luckhaus Christian, Hüll Michael, Gertz Hermann-Josef, Schröder Johannes, Hampel Harald, Teipel Stefan J, Pantel Johannes, Heuser Isabella, Wiltfang Jens, Rüther Eckart, Kornhuber Johannes, Maier Wolfgang, Meyer-Lindenberg Andreas

Abstract excerpt

BACKGROUND: Evidence has emerged indicating that the ε4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD. METHODS: The aim of this study was to investigate interaction effects of the APOE ε4 allele and the alleles at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Atrophy

Share to Cognition Disorders

Share to Genotyping Techniques

Share to Magnetic Resonance Imaging

Share to Monomeric Clathrin Assembly Proteins

Share to Neuropsychological Tests

Share to Organ Size

Source

Open in PubMed

Identifiers

PMID: 24613704
DOI: 10.1016/j.jalz.2013.11.001

Genes

APOE
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease.PMID 24613704Read ↗

The Effects of PICALM rs3851179 and Age on Brain Atrophy and Cognition Along the Alzheimer's Disease Continuum.Semantic proximity Read ↗

Correlation of PICALM polymorphism rs3851179 with Alzheimer's disease among Caucasian and Chinese populations: a meta-analysis and systematic review.Semantic proximity Read ↗

The Interactive Effects of Age and PICALM rs541458 Polymorphism on Cognitive Performance, Brain Structure, and Function in Non-demented Elderly.Semantic proximity Read ↗

PICALM rs3851179 Variant Confers Susceptibility to Alzheimer's Disease in Chinese Population.Semantic proximity Read ↗

Association of Alzheimer's disease risk variants on the PICALM gene with PICALM expression, core biomarkers, and feature neurodegeneration.Semantic proximity Read ↗

PICALM gene rs3851179 polymorphism contributes to Alzheimer's disease in an Asian population.Semantic proximity Read ↗

Investigation of Genetic Variants Associated with Alzheimer Disease in Parkinson Disease Cognition.Semantic proximity Read ↗

Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.Semantic proximity Read ↗

rs3851179G>A in PICALM is Protective Against Alzheimer's Disease in Five Different Countries Surrounding the Mediterranean.Semantic proximity Read ↗

Association of PICALM with Cognitive Impairment in Parkinson's Disease.Semantic proximity Read ↗

Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.