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Article

Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells

11 Aug 2020

Abstract excerpt

Success or failure of pancreatic beta cell adaptation to ER stress is a determinant of diabetes susceptibility. The ATF6 and IRE1/XBP1 pathways are separate ER stress-response effectors important to beta cell health and function. ATF6α. and XBP1 direct overlapping transcriptional responses in some cell types. However, the signaling dynamics and interdependence of ATF6α and XBP1 in pancreatic beta cells have not...

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Share to Endoplasmic Reticulum Stress and Disease
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PMID: 32788214
DOI: 10.1074/jbc.ra120.014173

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Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cellsPMID 32788214Read ↗

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