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Article

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

10 Mar 2015

Abstract excerpt

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protein-1 (sXBP1) is selectively impaired in DN, inducing activating transcription factor-6 (ATF6) and C/EBP homology...

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Share to Endoplasmic Reticulum Stress and Disease
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Share to Renal Diseases and Glomerulopathies

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PMID: 25754093
DOI: 10.1038/ncomms7496

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