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Article

Genetic Variation in Hydrochlorothiazide Response-Related Genes Among Hypertensive Individuals in Soweto, South Africa.

Clinical and translational science - 1 Jul 2025

Nyamupangedengu Kudakwashe, Twesigomwe David, May Andrew, Masimirembwa Collen, Martinson Neil, Waja Ziyaad, Letutu Matebogo, Ramsay Michèle

Abstract excerpt

Africa bears the largest burden of morbidity and mortality from hypertension (HT) and related cardiovascular diseases. Thiazide diuretics, including hydrochlorothiazide (HCTZ), are the most prescribed hypertension medicines globally due to their cost effectiveness and minimal side effects. However, studies investigating the genetic variation in HCTZ-related genes and their effect on drug response have been mainly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40681478
DOI: 10.1111/cts.70302
PMCID: PMC12274112

Genes

ALDH1A2
GNB3

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