Article
Cognitive deficits caused by a disease-mutation in the α3 Na(+)/K(+)-ATPase isoform.
Scientific reports - 23 Aug 2016
Holm Thomas Hellesøe, Isaksen Toke Jost, Glerup Simon, Heuck Anders, Bøttger Pernille, Füchtbauer Ernst-Martin, Nedergaard Steen, Nyengaard Jens Randel, Andreasen Mogens, Nissen Poul, Lykke-Hartmann Karin
Abstract excerpt
The Na(+)/K(+)-ATPases maintain Na(+) and K(+) electrochemical gradients across the plasma membrane, a prerequisite for electrical excitability and secondary transport in neurons. Autosomal dominant mutations in the human ATP1A3 gene encoding the neuron-specific Na(+)/K(+)-ATPase α3 isoform cause different neurological diseases, including rapid-onset dystonia-parkinsonism (RDP) and alternating hemiplegia of...
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