Article
Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder.
Molecular psychiatry - 1 Oct 2017
Lopez A Y, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina A M, Noebels J L, Sun Q-Q, Cooper E C
Abstract excerpt
ANK3, encoding the adaptor protein Ankyrin-G (AnkG), has been implicated in bipolar disorder by genome-wide association studies. ANK3 has multiple alternative first exons, and a bipolar disorder-associated ANK3 variant has been shown to reduce the expression of exon 1b. Here we identify mechanisms through which reduced ANK3 exon 1b isoform expression disrupts neuronal excitation-inhibition balance. We find that...
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