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Article

Poor outcome of pediatric patients with acute myeloid leukemia harboring high FLT3/ITD allelic ratios.

Nature communications - 27 Jun 2022

Qiu Kun-Yin, Liao Xiong-Yu, Liu Yong, Huang Ke, Li Yang, Fang Jian-Pei, Zhou Dun-Hua

Abstract excerpt

Activating FLT3 mutations are the most common mutations in acute myeloid leukemia (AML), but the optimal threshold of FLT3/ITD allelic ratio (AR) among pediatric AML patients remains controversial. Here, we present the outcome and prognostic significance of FLT3/ITD AR analysis among pediatric patients with AML from the TARGET dataset. Applying fitting curve models and threshold effect analysis using the...

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Identifiers

PMID: 35760968
DOI: 10.1038/s41467-022-31489-9
PMCID: PMC9237020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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