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Article

Poor outcome of pediatric patients with acute myeloid leukemia harboring high FLT3/ITD allelic ratios.

Nature communications - 27 Jun 2022

Qiu Kun-Yin, Liao Xiong-Yu, Liu Yong, Huang Ke, Li Yang, Fang Jian-Pei, Zhou Dun-Hua

Abstract excerpt

Activating FLT3 mutations are the most common mutations in acute myeloid leukemia (AML), but the optimal threshold of FLT3/ITD allelic ratio (AR) among pediatric AML patients remains controversial. Here, we present the outcome and prognostic significance of FLT3/ITD AR analysis among pediatric patients with AML from the TARGET dataset. Applying fitting curve models and threshold effect analysis using the...

Topics

Child
Genetic Testing
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute
Mutation
Stem Cell Transplantation
fms-Like Tyrosine Kinase 3

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35760968
DOI: 10.1038/s41467-022-31489-9
PMCID: PMC9237020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-35760968-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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