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Article

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia.

Blood - 15 Aug 2003

Meshinchi Soheil, Stirewalt Derek L, Alonzo Todd A, Zhang Quangeng, Sweetser David A, Woods William G, Bernstein Irwin D, Arceci Robert J, Radich Jerald P

Abstract excerpt

Activating mutations of receptor tyrosine kinases (RTKs) and their downstream affectors are common in acute myeloid leukemia (AML). We performed mutational analysis of FLT3, c-kit, c-fms, vascular endothelial growth factor (VEGF) receptors (Flt-1, KDR [kinase domain receptor]), and ras genes in a group of 91 pediatric patients with AML treated on Children's Cancer Group clinical trial CCG-2891. Forty-six percent...

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Source

Identifiers

PMID: 12702504
DOI: 10.1182/blood-2003-01-0137

Genes

FLT3
KDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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