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Article

The Clinical Utility of FLT3 Mutation Testing in Acute Leukemia: A Canadian Consensus.

Current oncology (Toronto, Ont.) - 12 Dec 2023

Bergeron Julie, Capo-Chichi Jose-Mario, Tsui Hubert, Mahe Etienne, Berardi Philip, Minden Mark D, Brandwein Joseph M, Schuh Andre C

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) mutations are detected in approximately 20-30% of patients with acute myeloid leukemia (AML), with the presence of a FLT3 internal tandem duplication (FLT3-ITD) mutation being associated with an inferior outcome. Assessment of FLT3 mutational status is now essential to define optimal upfront treatment in both newly diagnosed and relapsed AML, to support post-induction allogeneic...

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Identifiers

PMID: 38132393
DOI: 10.3390/curroncol30120759
PMCID: PMC10742150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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