Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: a report from the Children's Oncology Group.

Pediatric blood & cancer - 1 Oct 2012

Kutny Matthew A, Moser Barry K, Laumann Kristina, Feusner James H, Gamis Alan, Gregory John, Larson Richard A, Powell Bayard L, Stock Wendy, Willman Cheryl L, Woods William G, Meshinchi Soheil

Abstract excerpt

BACKGROUND: FLT3 mutations (FLT3/Mut) are prevalent in de novo AML and are associated with early relapse. The prevalence and prognostic significance of FLT3/Mut have not been well defined in childhood acute promyelocytic leukemia (APL). PROCEDURE: Diagnostic specimens from 104 pediatric APL patients were screened for FLT3/Mut (FLT3/ITD or FLT3/ALM). FLT3/Mut status was correlated with disease characteristics and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Infant

Share to Leukemia, Promyelocytic, Acute

Share to Leukocyte Count

Share to Prognosis

Share to Survival Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 22378655
DOI: 10.1002/pbc.24122
PMCID: PMC3368997

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: a report from the Children's Oncology Group.PMID 22378655Read ↗

Clinicopathological Significance of Common Genetic Alterations in Patients With Acute Promyelocytic Leukemia.Semantic proximity Read ↗

FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact.Semantic proximity Read ↗

FLT3 mutation and expression did not adversely affect clinical outcome of childhood acute leukaemia: a study of 531 Southeast Asian children by the Ma-Spore study group.Semantic proximity Read ↗

Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.Semantic proximity Read ↗

Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia.Semantic proximity Read ↗

Outcome of Childhood Acute Myeloid Leukemia With FLT3-ITD Mutation: The Experience of Children's Cancer Hospital Egypt, 2007-17.Semantic proximity Read ↗

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemiaSemantic proximity Read ↗

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia.Semantic proximity Read ↗

FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemiaSemantic proximity Read ↗

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia.Semantic proximity Read ↗

Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol.Semantic proximity Read ↗

FLT3-activating mutations are associated with poor prognostic features in AML at diagnosis but they are not an independent prognostic factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.