Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study.

doi:10.1007/s12185-017-2395-x

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Article

Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study.

International journal of hematology - 1 May 2018

Shimada Akira, Iijima-Yamashita Yuka, Tawa Akio, Tomizawa Daisuke, Yamada Miho, Norio Shiba, Watanabe Tomoyuki, Taga Takashi, Iwamoto Shotaro, Terui Kiminori, Moritake Hiroshi, Kinoshita Akitoshi, Takahashi Hiroyuki, Nakayama Hideki, Koh Katsuyoshi, Goto Hiroaki, Kosaka Yoshiyuki, Saito Akiko Moriya, Kiyokawa Nobutaka, Horibe Keizo, Hara Yusuke, Oki Kentaro, Hayashi Yasuhide, Tanaka Shiro, Adachi Souichi

Abstract excerpt

Acute myeloid leukemia harboring internal tandem duplication of FMS-like tyrosine kinase 3 (AMLFLT3-ITD) is associated with poor prognosis. We evaluated the results of the AML-05 study, in which all AMLFLT3-ITD patients were assigned to receive hematopoietic stem cell transplantation (HSCT) in the first remission (1CR). We also investigated the effects of additional genetic alterations on FLT3-ITD. The 5-year...

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PMID: 29330746
DOI: 10.1007/s12185-017-2395-x

Genes

EFS
FLT3
NSD1
NUP98
NPM1

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