Article
Immunohistochemical evaluation of EGFR protein expression and microvascular density reveals an angiogenic signature in Tunisian patients with metastatic colorectal cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Jun 2026
Gabteni Amira Jaballah, Ben Ayed Ines, Yaiche Hamza, Ben Jemii Nadia, Wider Dorra, Ardhaoui Monia, Fehri Emna, Maaloul Afifa, Habbechi Essia, Ennaifer Emna, Tounsi Haifa
Abstract excerpt
BACKGROUND: In metastatic colorectal cancer (mCRC), resistance to anti-EGFR monoclonal antibodies persists even in RAS/BRAF wild-type tumors. EGFR's role in tumor angiogenesis may contribute to this resistance and deserves further exploration. OBJECTIVE: To assess EGFR protein expression and angiogenesis using immunohistochemistry (IHC) in mCRC, and to perform a molecular study of EGFR hotspot mutations. PATIENTS...
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