Article
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis.
Cell death & disease - 2 Mar 2020
Yang Chunyuan, Chen Nan, Li Xiang, Lu Dan, Hou Zhiyuan, Li Yuhua, Jin Yan, Gu Jin, Yin Yuxin
Abstract excerpt
Metastasis is the leading cause of death for colorectal cancer (CRC). However, the protein transport process involved in CRC metastasis remains unclear. In this report, we use whole-exome sequencing and bioinformatics analysis to identify somatic mutations in CRC samples and found mutations of the protein transport gene Sec23 homolog B (SEC23B) in patients with metachronous liver metastasis. We show that deletion...
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