Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative Flagellin

1 Jun 2003

Abstract excerpt

Flagellins from Gram-negative bacteria activate inflammatory cells by a toll-like receptor 5 (TLR5)-dependent signaling pathway. We have examined the interaction between flagellin and TLR5 using an in vitro binding assay. Purified recombinant His-tagged flagellin from Salmonella enteritidis bound to TLR5 in detergent lysates from COS-1 cells transiently transfected with a human TLR5 expression plasmid. Flagellins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli research studies
Share to Immune Response and Inflammation
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12711596
DOI: 10.1074/jbc.m303481200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a Sequence in Human Toll-like Receptor 5 Required for the Binding of Gram-negative FlagellinPMID 12711596Read ↗

Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro.Semantic proximity Read ↗

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.Semantic proximity Read ↗

Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagellaSemantic proximity Read ↗

Determination of the physiological 2:2 TLR5:flagellin activation stoichiometry revealed by the activity of a fusion receptor.Semantic proximity Read ↗

Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin.Semantic proximity Read ↗

Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin.Semantic proximity Read ↗

Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5Semantic proximity Read ↗

Amino acids 89-96 of Salmonella typhimurium flagellin represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response.Semantic proximity Read ↗

A conserved TLR5 binding and activation hot spot on flagellin.Semantic proximity Read ↗

Clostridium difficile flagella predominantly activate TLR5-linked NF-κB pathway in epithelial cells.Semantic proximity Read ↗

Helicobacter pylori flagellin: TLR5 evasion and fusion-based conversion into a TLR5 agonistSemantic proximity Read ↗

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.