Article
Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number.
BMC genetics - 22 Dec 2016
Drozdova Polina, Mironova Ludmila, Zhouravleva Galina
Abstract excerpt
BACKGROUND: SUP35 and SUP45 are essential genes encoding polypeptide chain release factors. However, mutants for these genes may be viable but display pleiotropic phenotypes which include, but are not limited to, nonsense suppressor phenotype due to translation termination defect. [PSI +] prion formation is another Sup35p-associated mechanism leading to nonsense suppression through decreased availability of...
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