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Increased Arf/p53 activity in stem cells, aging and cancer

19 Jan 2017

Abstract excerpt

Arf/p53 pathway protects the cells against DNA damage induced by acute stress. This characteristic is the responsible for its tumor suppressor activity. Moreover, it regulates the chronic type of stress associated with aging. This is the basis of its anti-aging activity. Indeed, increased gene dosage of Arf/p53 displays elongated longevity and delayed aging. At a cellular level, it has been recently shown that...

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PMID: 28101907
DOI: 10.1111/acel.12574

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