Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration

16 Nov 2015

Abstract excerpt

The control of proliferation and differentiation by tumor suppressor genes suggests that evolution of divergent tumor suppressor repertoires could influence species' regenerative capacity. To directly test that premise, we humanized the zebrafish p53 pathway by introducing regulatory and coding sequences of the human tumor suppressor ARF into the zebrafish genome. ARF was dormant during development, in uninjured...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Hippo pathway signaling and YAP/TAZ

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26575287
DOI: 10.7554/elife.07702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regenerationPMID 26575287Read ↗

Buffering of genetic defects in animal development by regeneration programsSemantic proximity Read ↗

AI-Driven Comparative Genomics for Human Regenerative Gene Discovery Using Axolotl as a ModelSemantic proximity Read ↗

Non-Canonical Functions of the ARF Tumor Suppressor in Development and TumorigenesisSemantic proximity Read ↗

Tumor suppressors: enhancers or suppressors of regeneration?Semantic proximity Read ↗

Fgf signalling controls diverse aspects of fin regenerationSemantic proximity Read ↗

The EGFR signaling pathway controls gut progenitor differentiation during planarian regeneration and homeostasis.Semantic proximity Read ↗

Increased Arf/p53 activity in stem cells, aging and cancerSemantic proximity Read ↗

Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear.Semantic proximity Read ↗

p53 on the crossroad between regeneration and cancerSemantic proximity Read ↗

Post-Translational Regulation of ARF: Perspective in CancerSemantic proximity Read ↗

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.Semantic proximity Read ↗

Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotlsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.