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Article

Genomic profiling of pleomorphic and florid lobular carcinoma in situ reveals highly recurrent ERBB2 and ERRB3 alterations.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2020

Harrison Beth T, Nakhlis Faina, Dillon Deborah A, Soong T Rinda, Garcia Elizabeth P, Schnitt Stuart J, King Tari A

Abstract excerpt

Pleomorphic LCIS (P-LCIS) and florid LCIS (F-LCIS) are morphologic variants distinguished from classic LCIS by marked nuclear pleomorphism and/or an expansile growth pattern with or without necrosis. Given the rarity of these LCIS variants, little data exist regarding their molecular pathogenesis, natural history, and optimal management. The purpose of this study was to genomically profile LCIS variants to gain...

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PMID: 31932682
DOI: 10.1038/s41379-020-0459-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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