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Frequency of Pathogenic Germline Variants in CDH1, BRCA2, CHEK2, PALB2, BRCA1 , and TP53 in Sporadic Lobular Breast Cancer

1 Jul 2019

Abstract excerpt

Abstract Background: Invasive lobular breast cancer (ILC) accounts for approximately 15% of invasive breast carcinomas and is commonly associated with lobular carcinoma in situ (LCIS). Both have been shown to have higher familial risks than the more common ductal cancers. However, there are little data on the prevalence of the known high and moderate penetrance breast cancer predisposition genes in ILC. The aim...

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PMID: 31263054
DOI: 10.1158/1055-9965.epi-18-1102

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