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Article

pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma.

Neoplasia (New York, N.Y.) - 1 Feb 2017

Caruso James P, Koch Brandon J, Benson Philip D, Varughese Elsa, Monterey Michael D, Lee Amy E, Dave Ajal M, Kiousis Sam, Sloan Andrew E, Mathupala Saroj P

Abstract excerpt

Highly malignant brain tumors harbor the aberrant propensity for aerobic glycolysis, the excessive conversion of glucose to lactic acid even in the presence of ample tissue oxygen. Lactic acid is rapidly effluxed to the tumor microenvironment via a group of plasma-membrane transporters denoted monocarboxylate transporters (MCTs) to prevent "self-poisoning." One isoform, MCT2, has the highest affinity for lactate...

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Identifiers

PMID: 28092823
DOI: 10.1016/j.neo.2016.12.011
PMCID: PMC5238458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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