Article

MCT4 is a high affinity transporter capable of exporting lactate in high-lactate environments

2019-03-27

Abstract excerpt

MCT4 is an H + -coupled transporter expressed in metastatic cancer cells, macrophages, and other highly glycolytic cells, where it extrudes excess lactate generated by the Warburg phenomenon or by hypoxia. Intriguingly, its reported K m for lactate, obtained with pH-sensitive probes, is more than an order of magnitude higher than physiological lactate. Here we examined MCT4-rich MDA-MB-231 cells using the FRET s...

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Literature Corpus work: 69f69472-0293-58a8-9aea-9b1a923835e5
DOI: 10.1101/586966

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