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Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function

8 Aug 2022

Abstract excerpt

Brain activity is constrained by local availability of chemical energy, which is generated through compartmentalized metabolic processes. By analyzing data of whole human brain gene expression, we characterize the spatial distribution of seven glucose and monocarboxylate membrane transporters that mediate astrocyte-neuron lactate shuttle transfer of energy. We found that the gene coding for neuronal MCT2 is the...

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PMID: 35939682
DOI: 10.1073/pnas.2204619119

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