Article

Lactate cannot replace glucose for maintaining the viability of mouse and human glioma cells

2025-06-06

Abstract excerpt

<h4>Objectives</h4> Aerobic lactic acid fermentation (the “Warburg effect”) is associated with OxPhos insufficiency and altered energy metabolism in most cancers. Whether lactate is a major fuel in cancer cells remains debated. This study investigated whether lactate could serve as a metabolic fuel in glioma cells and replace glucose to support viability. <h4>Methods</h4> A bioluminescence ATP assay and calcein-...

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Literature Corpus work: c3138ed4-55ec-5982-858e-e6021e6ba322
DOI: 10.1101/2025.06.03.655413

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