Article
Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity.
Oncotarget - 15 Sept 2014
Chittaranjan Suganthi, Chan Susanna, Yang Cindy, Yang Kevin C, Chen Vincent, Moradian Annie, Firme Marlo, Song Jungeun, Go Nancy E, Blough Michael D, Chan Jennifer A, Cairncross J Gregory, Gorski Sharon M, Morin Gregg B, Yip Stephen, Marra Marco A
Abstract excerpt
The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K). Approximately 70% of ODGs with 1p19q co-deletions harbor somatic mutations in the Capicua Transcriptional Repressor (CIC) gene on chromosome 19q13.2. Here we show that endogenous long (CIC-L) and short (CIC-S) CIC proteins are predominantly localized to...
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